NSBCC

Biaoyang Lin, Ph.D.

 



BIOGRAPHICAL SKETCH

 

NAME

 

Biaoyang Lin

POSITION TITLE

 

Senior Research Scientist

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

 Xiamen University, Xiamen, China   

B.S.

1984

Biology

Shanghai Institute of Plant Physiology, China

M.S.

1987

Genetic Engineering

University of British Columbia, Vancouver, Canada

Ph.D.

1994

Medical Genetics

CONTINUED EDUCATION:

  Southwest Oncology Group

Certificate

2001

Clinical associate

 

 

 

 

 

A.                 Positions and Honors

Positions

1984-1987         Research Assistant, Dept. of Genetic Engineering, Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, Shanghai, China

1987-1990         Lecturer and Research Scientist, Shanghai Second Medical University, Shanghai, China

1988-1990         Research Scientist, Dept. of Molecular Biology, Shanghai Institute of Physiology, Chinese Academy of  Sciences, Shanghai, China

1990-1994         Research Assistant, Dept. of medical Genetics, University of B.C. Vancouver, Canada

1994-1996         ICRF Research Fellow, Department of Molecular Analysis of Mammalian Mutations, Imperial Cancer Research Fund, London, U.K.

1996-1997         Alexander von Humboldt Scholar, Inst. of Human Genetics, University of Wuerzburg, Germany and Max-Planck Institute for Immunobiology, Freiburg, Germany

1997-1998         Research Associate, Department of Molecular Medicine, Northwest Hospital, Seattle, WA

1998-2000         Acting Instructor, Department of Molecular Biotechnology and Dept. of Urology, University of Washington, Seattle,WA

2000-present     Senior Research Scientist and Head of Cancer Research Group, Institute for Systems Biology, Seattle, WA

2003-present     Affiliate Assistant Professor, Dept. of Urology, University of Washington, Seattle, WA.

 

Honors

1982-1984                   Excellent Student Award, Three times, Xiamen (Amoy) University, Xiamen, China

1985-1986                   Excellent Graduate Student Award, Twice, Shanghai Institute of Plant Physiology, Chinese                                    Academy of Sciences, Shanghai, PR of China

1989                            Excellent lecturer Award, Shanghai 2nd Medical University, Shanghai, PR. of China

1990                            Silver Excellent Research Prize, awarded by Tibet  Government

1993-1994                   UBC University Graduate Fellowship, University of British Columbia, Vancouver, B.C.

1994-1996                   ICRF Postdoctoral Fellowship, Imperial Cancer Research Fund (ICRF), London, U. K.

1996-1997                                       Alexander Von Humboldt scholarship, Germany

2003-2003                                SPORE Career development award, NCI, USA

 

B.  Selected peer-reviewed publications

Lin B, Wang X.P, Ru Y, Bao Y.D, Chen R.B.  A simplified method of isolating mt DNA from frozen human placenta, Chinese Journal of Heredity and Disease, 8: 100-101, 1991.

Weber B, Reiss O, Hutchinson G, Collins C, Lin B, Kowbel D, Andrew S, Schappert K, Hayden M.R. Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its location to 4p16.3., Nucleic Acid Research, 19: 6263-6268, 1991.

 

Wang X.P, Lin B, Ru Y, Qi M, Fei H.M, Bao Y.D, Zhan W.F, Chen R.B.  RFLP analysis of mt DNA in Tibetan populations, Chinese journal of Hereditas, 14: 24-26, 1992.

Lin B*, Goldberg Y.P*,  Andrew S.E, Nasir J, Graham R, Glaves M.L, Hutchinson G, Theilmann J, Ginzinger D.G, Schappert K, Clarke L, Rommens J.M, Hayden M.R, Cloning and mapping of the alpha-adducin gene closed to D4S95 and assessment of its relationship to Huntington disease, Human Molecular Genetics, 1: 669-675, 1992. (*:  Co-first authors)

Goldberg Y.P, Rommens J.M, Andrew S.E, Hutchinson G.B, Lin B, Theilmann J, Graham R, Glaves M.L, Starr E, McDonald H, Nasir J, Schappert K, Kalchman M.A, Clark L.A, Hayden M.R. Identification of an Alu retrotransposition event in close proximity to a strong candidate gene for Huntington’s disease. Nature, 362: 370-373,1993.

Andrew S.E,  Goldberg Y.P, Kremer B, Telenius H, Theilmann J, Adam S, Starr E, Squitieri F, Lin B, Kalchman M.A, Graham R.K, Hayden M.R.  The relationship between trinucleotide repeat (CAG) length and clinical features of Huntington disease.  Nature Genetics, 4: 398-403, 1993.

Rommens J.M, Lin B, Hutchinson G.B, Andrew S.E, Goldberg Y.P, Glaves M.L, Graham R, Lai V, McArthur J, Nasir J, Theilmann J, McDonald H, Kalchman M, Clark L.A,  Schappert K, Hayden M.R.  A transcription map of the region containing the Huntington disease gene.  Human Molecular Genetics, 2: 901-907, 1993.

Lin B., Rommens J.M., Graham R.K., Kalchman M., MacDonald H., Nasir J.,  Delaney A., Goldberg Y.P. and Hayden M.R.  Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression.  Hum. Mol. Genet. 2: 1541-1545, 1993.

Lin B, Nasir J, MacDonald H, Hutchinson G, Graham, R, Rommens, J.M, Hayden, M.R.  Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat.  Hum Mol Genet.,3: 85-92, 1994.

Kremer B, Goldberg P,Andrew S.E, Squitieri F, Theilmann J, Telenius H, Zeisler J, Lin B, Adam S, Benjamin C, Greenberg J, Lucotte G, Almqvist E, Bird T, Schellenberg G.D, Kennedy J, Petronius A, Bassett A, Anvret M, Hayden M.R.  Worldwide distribution of the Huntington disease (HD) mutation:The sensitivity and specificity of CAG repeat length assessment, New Engl J  Med., 330:1401-1406, 1994.

Nasir J., Lin B., Bucan M., Nadeau J., and Hayden M.R.  The murine homologue of the Huntington disease gene maps on mouse chromosome 5 within a region of synteny with human chromosome 4p16.3, Genomics., 22:198-201, 1994.

Fei H., Lu Y., Lin B., Jiang W., Zou Y., Chen R.B. Nucleotide sequence analysis of a new DR15(2) allele from Yi nationality in China. Chinese J. Microbiology and Immunology, 340-345, 1995.

Lin B, Nasir J, Kalchman, M, McDonald H, Zeisler, J, Goldberg, YP, Hayden, MR.  Structural analysis of the 5' region of mouse and human Huntington disease genes revelas conservation of putative promoter region and di- and trinucleotide polymorphisms. Genomics, 25: 707-715, 1995.

Lin B., Nasir J., McDonald H., Graham R., Rommens J.M., Goldberg Y.P., Hayden, M.R. Genomic  organization of the human alpha-adducin gene and its alternate messenger RNA isoforms. Genomics, 25:93-106, 1995.

Lin, B., Ferfuson, C., White, J.T., Wang, S., Vessella, R., True, L.D., Hood, L. and Nelson, P.S. Prostate-localized and androgen regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res. 59:4180-84, 1999.

Lin B, White JT, Ferguson C, Bumgarner R, Friedman C, Trask B, Ellis W, Lange P, Hood L, Nelson PS. PART-1: a novel human prostate-specific, androgen-regulated gene that maps to chromosome 5q12. Cancer Res 60:858-63, 2000.

Nelson P.S, Han D.,  Rochon Y., Corthals G.L., Lin B., Monson A., Nyugen V., Franza B.R., Plymate S.R.., Aebersold R. and Hood L. Comprehensive analysis of prostate gene expression: convergence of expressed sequence tag databases, transcript profiling and proteomics. Electrophoresis 21:1823-31, 2000

Lin B., White JT, Ferguson, C., Wang S., Vessella R., Bumgarner R., True, LD., Hood, L., Nelson, PS. PSDR1: a prostate-localized member of the short-chain steroid dehydrogenase/reductase (SDR) family highly expressed in the normal and neoplastic prostate epithelium. Cancer Research , 61:1611-8, 2001.

Huang, R., Lin, Y., Wang, C.C., Gano J., Lin B., Shi, Q., Boynton A., Burke. J. and Huang, R-P. (2002) Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1 as discovered using protein array technology, Cancer Research 62: 2806-12.

Moore, S., Pritchard, C., Lin, B., Ferguson, C., and Nelson, P. S. (2002) Isolation and characterization of the murine prostate short-chain dehydrogenase/reductase 1 (Psdr1) gene, a new member of the short-chain steroid dehydrogenase/reductase family, Gene. 293: 149-60.

Nelson, P. S., Clegg, N., Arnold, H., Ferguson, C., Bonham, M., White, J., Hood, L., and Lin, B. (2002) The program of androgen-responsive genes in neoplastic prostate epithelium, Proc Natl Acad Sci U S A. 99: 11890-5.

Weber, B. H., Lin, B., White, K., Kohler, K., Soboleva, G., Herterich, S., Seeliger, M. W., Jaissle, G. B., Grimm, C., Reme, C., Wenzel, A., Asan, E., and Schrewe, H. (2002) A mouse model for Sorsby fundus dystrophy, Invest Ophthalmol Vis Sci. 43: 2732-40.

Utleg, A., Yi, E. Y., Tao, X., Shannon, P. White, J.T., Goodlett, D., Hood, L. and Lin, B. (2003) Proteomic analysis of the human prostasome, Prostate, 56:150-161.

Lin, B*., White, J.T., Utleg, A.G., Wang, S, Ferguson C., True, L. D. Vessella R., Hood, L. and Nelson PS. (2002) Cloning and characterization of human and mouse WDR19, a novel WD-repeat protein that shows androgen-regulated expression in prostate cells, Genomics, 82:331-342 (2003) (* corresponding author).

Hood L, Heath JR, Phelps ME, Lin B: Systems biology and new technologies enable predictive and preventative medicine. Science 2004, 306(5696):640-643.

Desiere, F., Deutsch, E.W., Nesvizhskii, A.I., Mallick, P., King, N., Eng,J.K., Aderem, A., Boyle, R., Brunner, E., Sonohoe, S., Hafen, E., Hood, L., Katze, M.G., Kennedy, K., Kregenow, F., Lee, H., Lin, B., et al. Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol 2005;6(1):R9.

Halvorsen O. J., Oyan A. M., Bo T. H., Olsen S., Rostad K., Haukaas S. A., Bakke A. M., Marzolf B., Dimitrov K., Stordrange L., Lin B., Jonassen I., Hood L., Akslen L. A., and Kalland K. H. (2005). Gene expression profiles in prostate cancer: Association with patient subgroups and tumour differentiation. Int J Oncol 26: 329-36.

Lin, B*., J. T. White, W. Lu, T. Xie, A. G. Utleg, X. Yan, E. C. Yi, P. Shannon, I. Khrebtukova, P. H. Lange, D. R. Goodlett, D. Zhou, T. J. Vasicek and L. Hood (2005). Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease. Cancer Res 65(8): 3081-91. (* corresponding author).

Stewart, J. J., J. T. White, X. Yan, S. Collins, C. W. Drescher, N. D. Urban, L. Hood and B. Lin. (2006). Proteins associated with cisplatin resistance in ovarian cancer cells identified by quantitative proteomics technology and integrated with mRNA expression levels, Molecular and cellular proteomics in press.

Lu, W., D. Zhou, G. Glusman, A. G. Utleg, J. T. White, P. S. Nelson, T. J. Vasicek, L. Hood and B. Lin (2006). KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cells. Prostate in press.

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