Ruedi Aebersold, PhD

Dr. Ruedi Aebersold, one of the pioneers in the field of proteomics, is known for developing a series of methods that have found wide application in analytical protein chemistry and proteomics. Most recently, his group developed a method for the rapid identification and accurate quantification of cellular proteins, i.e. for the generation of cellular "protein profiles";. The method is based on a new class of reagents termed Isotope Coded Affinity Tags or ICAT reagents, and mass spectrometry. Dr. Aebersold and his team of researchers use the "protein profiles" determined by the method to differentiate cells in different states, such as noncancerous vs. cancerous cells, and to systematically study how cells respond to external stimuli. These "snapshot" profiles indicate which cells contain abnormal levels of certain proteins. This is expected to lead to new diagnostic markers for disease and to a more complete understanding of the biochemical processes that control and constitute cell physiology.

Dr. Aebersold is a native of Switzerland and earned his Ph.D. in Cellular Biology at the Biocenter of the University of Basel in 1983. Since that time, he served on the faculties of the Universities of Washington and British Columbia, until 2000, when he co-founded the Institute for Systems Biology with Drs. Leroy Hood and Alan Aderem.

Dr. Aebersold also serves on the Scientific Advisory Committees of a number of academic and private sector research organizations and is a member of several editorial boards in the fields of protein science, genomics, and proteomics. Dr. Aebersold's research group and the ISB High Throughput Proteomics facility continue to refine robust proteomics technology and to identify and quantify thousands of proteins daily.

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