NSBCC Publications
Cross-species comparisons of cancer signaling. Nat Genet. 2005 37:7-8 (Graeber & Sawyers)
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer Cancer Cell 4 209-221
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H.
Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, 90095, Los Angeles, CA, USA
The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.
Myc-driven murine prostate cancer...Cancer Cell 2003:(4) 223-238 (Sawyers)
Micro lab makes cheap PET scan ingredient
Nanobiotech News Press Release
Systems Biology an New Technologies Enable Predictive and Preventative Medicine
New Microchip Technology for Medical Imaging Biomarkers of Disease Developed
© 2005, NSBCC: NanoSystems Biology Cancer Center
Caltech Chemistry 127-72 1200 East California Blvd.
Pasadena, CA 91125
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